Creatine: what are the alternatives?
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Creatine: what are the alternatives?

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At a time like this, when the supply of raw materials is under strain from a succession and convergence of world events, not only the main production chains but also those linked to food supplements are facing serious difficulties.

Add to this the constant desire of the most demanding consumers to research, try and evaluate new and innovative products, and it is easy to see why interest is growing in possible alternatives to a molecule like Creatine. We are talking about an extremely well-known molecule, used by many, studied by many, recommended, mythologised, criticised ("creatine is bad for you") and then strongly promoted again, which nonetheless retains over time all the scientific evidence for its biochemical activity, fundamental to energy production in cellular processes.

The more accurate question to ask, in fact, would be: is it possible to replace a Creatine supplement with something similar?
Creatine is an amino acid derivative produced by our body in limited amounts over twenty-four hours, also obtained from food and needed for energy-producing biochemical reactions at cellular level. It is the molecule that allows us to restore ATP once it has been broken down to release energy. This is the main effect of creatine.

Without going into biochemical detail, it is a bit as if ATP molecules were bundles of firewood used to keep our home warm, which every so often lose a few logs as the fire burns, and our Creatine were the person in charge of topping the bundle up with more wood: without Creatine, even with ATP available, we could not release energy to move, run, jump, lift weights and so on.

As mentioned, exogenous Creatine, i.e. the Creatine obtained from the diet, supplements the Creatine produced by the body, endogenous Creatine, to provide a total daily amount that meets the individual's needs. This amount is around 2-3 g a day for inactive or not very active people. While it is true that we could easily reach this amount through food, it is also true that cooking and processing some Creatine-rich foods reduce the exogenous amount provided, just as the increased needs of moderately or very muscularly active people create the conditions for a greater requirement. This explains the physiological need to supplement Creatine, especially for some athletes. There are several types of creatine on the market; the best known and most widely used is creatine monohydrate. It is available both as a powder and in tablets.

Given the particular mechanism of action of the creatine molecule, it will not be possible to replace it with another molecule that "mimics" the same action. We could therefore only turn our attention to supplements that can support recovery in general, but never the specific process of ATP resynthesis for which Creatine is responsible.

Looking at other compounds that are very useful for energy and mechanical recovery after intense muscle contractions, it may be worth considering branched-chain amino acids, the well-known BCAA, or the broader group of Essential Amino Acids, or Glutamine or Arginine. These are all amino acids or amino acid derivatives useful for tissue trophism, for restoring and repairing muscle fibres damaged by contraction, or for helping to clear the excess waste products and toxins produced during exertion by increasing blood flow, as in the case of Arginine.

All this would certainly help us feel better after very intense exercise, get ready for the next training session and shorten recovery times, but if we really wanted to benefit from the specific contribution of Creatine, we would necessarily have to turn to natural sources taken through the diet. Meat and fish are among the best foods in this respect, with, for example, 5 g of creatine per kg of pork or 4 g per kg of tuna. For this reason, vegans and vegetarians may have lower Creatine levels and therefore may need specific supplementation if required. Be careful, though: as already mentioned, cooking can change the amount of Creatine absorbed, so 250 g of pork a day, for example, may not be enough to make up the exogenous share of Creatine, especially for dedicated athletes who need larger amounts.

In short, Creatine is really difficult, if not impossible, to replace if we were looking for a perfect substitute: we could restore energy supplies from sources other than ATP, but these differ according to the biochemical processes they are involved in, so we would be talking about rather different things, a bit like trying to replace a good motorbike with a more modest bicycle: the goal might not be reached or, at the very least, not in the same time, in the same way or with the same effort.

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